Spatial Analysis

A personalized multi-omics discovery and validation platform for recurrent head and neck squamous cell carcinoma (POLARES)

Group Giger   Head and Neck Anticancer Center
                                  POLARES Research Group
Diagnostic and therapeutic developments in recent years have improved the prognosis for patients with head and neck squamous cell carcinoma (HNSCC). Despite these developments, a significant proportion of patients relapse after an initial response to standard treatment. Salvage treatment options are limited, and personalized treatment approaches that consider the genomic/epigenetic landscape of the tumor are lacking. The goal of this research is to establish a center of excellence in HNSCC that bridges the gap between genomic analysis and translation of findings into clinical trials. By establishing a multi-omics discovery and validation platform under the umbrella of the University Cancer Center Inselspital (UCI), this consortium (ORL, Head and Neck Surgery; Medical Oncology; Radiation-Oncology) aims to determine how alterations at the genomic and epigenetic level regulate carcinogenesis, treatment response and resistance in HNSCC and thereby identify novel mechanisms to target tumor relapse.

On behalf of the Consortium:
Prof. Dr. Roland Giger (Lead), Otorhinolaryngology, Head and Neck Surgery; PD Dr. Olgun Elicin, Radio-Oncology; Dr. Simon Häfliger, Medical Oncology; PD Dr. Michaela Medová, Radio-Oncology, DBMR; Prof. Dr. Carsten Riether, Medical Oncology, DBMR; Dr. Daniel H. Schanne, Radio-Oncology