Our Ccommitment to Research and Teaching
The Head and Neck Tumor Center and its University partner clinics are committed to providing the best possible treatment for every patient. We strive to use our research to contribute valuable results to a better understanding of cancer and to the continuous improvement of cancer therapy.
In addition to research, communicating our knowledge is also important to us. As part of the University Center, we work closely with the medical faculty of the University of Bern. Our employees hold regular lectures for medical students. In addition, our partner clinics run practical courses and enable clinical internships for medical students.
Best-of-EORTC 1420
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Title in German |
Phase III Studie zur Beurteilung der Strahlentherapie (IMRT) im Vergleich zur minimal invasive Chirurgie (trans-orale Laser- oder Roboter-gestützte Chirurgie, (TLM, TORS)) bei Patienten mit T1–2N0-1 Oropharynxkarzinomen, T1-2N0-1 supraglottischen Larynxkarzinomen und T1N0 Hypopharynxkarzinomen Studie zur Klärung der besten Therapie bei Rachenkrebs im Frühstadium. |
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Title in English |
EORTC 1420 - Phase III study assessing the “best of” radiotherapy compared to the “best of” surgery (trans-oral surgery (TOS)) in patients with T1-T2, N0 oropharyngeal carcinoma. |
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Description |
The study examines the extent to which surgery or radiation therapy influences the recovery of normal swallowing function after treatment of an early-stage malignant tumor in the pharynx. |
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Both forms of treatment are already being used successfully today, but so far there has been no clarification as to which therapy is better with regard to swallowing function. |
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This study is being carried out jointly at several clinics in Switzerland and Europe. 170 patients are to be treated and examined as part of the study within 2 years. |
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Phase/Biobank/etc. |
Phase III |
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Studienleiter |
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Status |
19.12.2017 |
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BASEC-Nummer |
2017-01600 |
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KOFAM |
SNCTP000002375 |
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WHO-Register-Nummer |
NCT02984410 |
DeIntensiF
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Title in German |
Vergleich einer individualisierten Nachsorge mit verstärkter Patient*innen-Mitwirkung und verminderten Standard-Kontrollen mit der herkömmlichen Nachsorge nach einer auf vollständige Heilung ausgerichteten Behandlung von Kopf-Hals-Krebs |
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Title in English |
DeintensiF: Multicenter randomized trial comparing an individualized de-intensified and conventional follow-up strategy after curative treatment in head and neck cancer |
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Descpription |
This study is primarily intended to examine the difference between individualized follow-up care with increased patient involvement and reduced standard controls and conventional standard follow-up care in patients with moderately to severely advanced head and neck cancer from 6 months after complete treatment Cure-oriented treatment and complete clinical and imaging disappearance of the tumor. |
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Phase/Biobank/etc. |
Pilot study |
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Head Clinical Trial |
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Study-Nurse |
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Back-up |
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Status |
active since 12.10.2022 |
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BASEC-Nummer |
2022-00966 |
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KOFAM |
SNCTP000005198 |
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WHO-Register-Nummer |
ClinicalTrials.gov ID: NCT05388136 |
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Insel-Nummer |
DLF-Nr: 5240 |
LBB-FUP
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Title in German |
Flüssige Biopsien für die Nachsorge der Patienten mit Kopf- und Halskrebs |
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Title in English |
Circulating Biomarkers to Monitor Therapeutic Response of Head and Neck Cancer |
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Description |
With this research project we would like to determine the diagnostic value of so-called liquid biopsies in the context of tumor follow-up for patients with head and neck cancer. A liquid biopsy is used to obtain information about cancer from a blood sample. Above all, we would like to know whether it is possible to examine and monitor the disease using liquid biopsy-based methods. In the future, liquid biopsy could potentially also be used for early detection of cancer and cancer relapses. |
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So far, liquid biopsy-based tests have mostly been experimental and not standard procedures. They should therefore be used in clinical studies. To achieve this goal, we will compare the analyzes of the liquid biopsies with the results of the imaging and, if necessary, the tissue samples. This pilot study will only be carried out in the Inselspital and we would like to recruit around 30 patients in the first phase. |
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Phase/Biobank/etc. |
Biobank |
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Studienleiter |
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Status |
active since 01.09.2019 |
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BASEC-Nummer |
20189-00764 |
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KOFAM |
keine |
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WHO-Register-Nummer |
keine |
LBB-TOX
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Title in German |
Blutproben zur Vorhersage von Radio-Chemotherapie-Nebenwirkungen bei Patienten mit fortgeschrittenem Kopf-Hals-Tumor |
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Title in English |
A single-cell proteomics approach to predict chemoradiation-induced toxicities in patients with advanced head and neck squamous cell carcinoma |
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Description |
With this research project we would like to determine the diagnostic value of blood samples in the context of tumor therapy for patients with head and neck cancer. A blood sample is used to obtain information about cancer. Above all, we would like to know whether it is possible to predict the disease or side effects of the therapy using blood sample-based methods. So far, the tests with blood samples have mostly been experimental and not a standard procedure. They should therefore be used in clinical studies. To achieve this goal, we will compare the analyzes of the blood samples with the occurrence of side effects of therapy and imaging of the disease status after 4 months. This pilot study will only be carried out in the Inselspital and we would like to include around 30 patients in the first phase. |
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Phase/Biobank/etc. |
Biobank |
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Studienleiter |
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Status |
active since 23.01.2020 |
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BASEC-Nummer |
2019-00863 |
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KOFAM |
keine |
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WHO-Register-Nummer |
keine |
POLARES
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Title in German |
Personalisierte Plattform zur molekularen Charakterisierung von Kopf-Hals-Tumoren und Tumorrezidiven |
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Title in English |
Personalized discovery and validation multi-Omics pLAtform for Recurrent hEad and Neck Squamous Cell Carcinoma (POLARES) |
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Description |
In this project, the collected biological material will be examined in order to gain further knowledge in the area of the cause, detection and treatment of tumor diseases in the head and neck area. The biological material obtained in this way is linked to the associated personal and treatment data. |
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Phase/Biobank/etc. |
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Heads Clinical Trial |
Prof. Carsten Riether, PhD (Riether Lab); PD Dr. Michaela Medová (Medova Lab); Dr. med. Simon Häfliger (Häfliger Lab); Prof. Dr. med. Roland Giger (HNO) |
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Study-Nurse |
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Back-up |
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Status |
active since 04.10.2022 |
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BASEC-Nummer |
2022-00543 |
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KOFAM |
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WHO-Register-Nummer |
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Insel-Nummer |
VoiceDetect
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Title in German |
Die Stimme zur Erkennung von Kehlkopf- und Rachenkrebsrückfällen - eine Machbarkeitsstudie |
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Title in English |
The Voice as a tool to Detect recurrence of laryngeal and hypopharyngeal cancer - a feasibility study |
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Description |
The aim of this research project is to examine the feasibility of long-term, regular voice monitoring in laryngeal and hypopharyngeal cancer patients, particularly with regard to their follow-up adherence. All patients with squamous cell carcinoma of the larynx/hypopharynx (exclusively after total laryngectomy) who have successfully completed primary curative treatment 6-30 months ago will receive three-monthly voice recordings and fiber endoscopic examinations (examination using a flexible camera) over a period of at least six months. carried out. In addition, a subjective assessment of the patient's own voice problems is carried out at each study visit using the Voice Handicap Index 30 questionnaire. Ultimately, it is about determining and analyzing intra-individual voice changes, i.e. voice changes in patients over time, and correlating these objective voice changes with the subjective voice changes (questionnaire) and the clinical changes in the larynx/hypopharynx (flexible camera examination). |
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Phase/Biobank/etc. |
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Head Clinical Trial |
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Study-Nurse |
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Back-up |
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Status |
active since 01.07.2023 |
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BASEC-Nummer |
2023-00838 |
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KOFAM |
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WHO-Register-Nummer |
ClinicalTrials.gov ID:NCT05894070 |
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Insel-Nummer |
VoiceS
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Title in German |
VoiceS: Stimmqualität nach transoraler CO2-Lasermikrochirurgie im Vergleich zur singulären Stimmbandbestrahlung bei einseitigem glottischem Frühkarzinom – Multizentrische randomisierte Phase III Studie |
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Title in English |
VoiceS: Voice Quality after Transoral CO2-Laser Surgery versus Single Vocal Cord Irradiation for Unilateral Stage 0 & I Glottic Larynx Cancer – A Randomized Phase III Trial |
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Description |
There are two equivalent treatment options for early-stage vocal fold carcinoma: endoscopic laser surgery or radiation therapy. According to medical literature, both treatment options show comparable results in terms of chances of curing the tumor and voice quality. However, all studies conducted and published to date have been carried out using less than ideal methodology. Patients who were evaluated in these studies either actively decided on one of the two types of therapy themselves or their “correct” treatment was given to them by the treating physicians. |
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Our study focuses primarily on long-term voice quality. As part of this study, the type of therapy for each patient (surgery or radiotherapy) is determined not by the doctors or the patients themselves, but by a random generator using a computer program. This results in a study with greater scientific validity. |
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Today, surgical and radiotherapeutic treatments are carried out using the most modern organ-preserving techniques and are regularly checked for quality. The biostatistical calculations carried out in advance show that 34 patients are needed to complete the study successfully and with a sufficiently high level of significance. In each canton in which the study is carried out, a review is carried out by the responsible ethics committee. |
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Phase/Biobank/etc. |
Phase III |
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Studienleiter |
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Status |
active since 15.01.2020 |
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BASEC Nummer |
2019-01506 |
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KOFAM |
SNCTP000003599 |
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WHO-Register-Nummer |
NCT04057209 |
Publications
Here you will find a selection of publications on tumors in the head and neck area that were published by the participating clinics of the Head and Neck Tumor Center.
Publikations 2020
Comparison of Current Surgical and Non-Surgical Treatment Strategies for Early and Locally Advanced Stage Glottic Laryngeal Cancer and Their Outcome Olgun Elicin 1, Roland Giger 2 Affiliations expand PMID: 32244899 PMCID: PMC7140062 DOI: 10.3390/cancers12030732 Free PMC article
Xu-Shan Sun 1, Yungan Tao 2, Christophe Le Tourneau 3, Yoann Pointreau 4, Christian Sire 5, Marie-Christine Kaminsky 6, Alexandre Coutte 7, Marc Alfonsi 8, Pierre Boisselier 9, Laurent Martin 10, Jessica Miroir 11, Jean-Francois Ramee 12, Jean-Pierre Delord 13, Florian Clatot 14, Frederic Rolland 15, Julie Villa 16, Nicolas Magne 17, Olgun Elicin 18, Elisabeta Gherga 1, France Nguyen 2, Cedrick Lafond 4, Guillaume Bera 5, Valentin Calugaru 3, Lionnel Geoffrois 6, Bruno Chauffert 7, Angela Zubel 19, Claudio Zanna 19, Silvano Brienza 19, Philippa Crompton 19, Elisabeth Rouits 19, Kathrin Gollmer 19, Sergio Szyldergemajn 19, Jean Bourhis 20
Affiliations expand
PMID: 32758455 DOI: 10.1016/S1470-2045(20)30327-2
Sven Beckmann 1, Matthias S Dettmer 2, Marco D Caversaccio 1, Roland Giger 1, Lukas Anschuetz 1
Affiliations expand
PMID: 32443830 PMCID: PMC7279297 DOI: 10.3390/medicina56050248
Free PMC article
Beat Bojaxhiu 1 2 3, Binaya K Shrestha 1, Pascal Luterbacher 1, Olgun Elicin 1, Mohamed Shelan 1, Andrew J S Macpherson 4, Benjamin Heimgartner 4, Roland Giger 5, Daniel M Aebersold 1, Kathrin Zaugg 6 7
Affiliations expand
PMID: 33317602 PMCID: PMC7737384 DOI: 10.1186/s13014-020-01727-9
Free PMC articl
Publikations 2019
Mueller SA, Riggauer J, Elicin O, Blaser D, Trelle S, Giger R.
Head Neck. 2019 Jul;41(7):2174-2181. doi: 10.1002/hed.25686. Epub 2019 Feb 5.
PMID: 30723984
Multimodal Imaging With Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging to Detect Extracapsular Extension in Head and Neck Cancer.
Sheppard SC, Giger R, Bojaxhiu B, Sachpekidis C, Dammann F, Dettmer MS, Arnold A, Wartenberg J, Nisa L.
Laryngoscope. 2020 Mar 6. doi: 10.1002/lary.28602. [Epub ahead of print] 2.3430.780
Effect of Preoperative Immunonutrition on Complications after Salvage Surgery in Recurrent Head and Neck Cancer.
Mueller SA, Aeberhard C, Mayer C, Meyer S, Schuetz P, Stanga Z, Giger R.
JOtolHNS 2019, doi: 10.1186/s40463-019-0345-8. 1.7040.585
Elicin O, Sermaxhaj B, Bojaxhiu B, Shelan M, Giger R, Rauch D, Aebersold DM.
Strahlenther Onkol. 2019 Jun;195(6):468-474. doi: 10.1007/s00066-018-1400-5. Epub 2018 Nov 21.
PMID: 30465265 English.
Long-term functional outcome after laryngeal cancer treatment.
Anschuetz L, Shelan M, Dematté M, Schubert AD, Giger R, Elicin O.
Radiat Oncol. 2019 Jun 11;14(1):101. doi: 10.1186/s13014-019-1299-8.
PMID: 31186027
Stelmes JJ, Gregoire V, Poorten VV, Golusiñski W, Szewczyk M, Jones T, Ansarin M, Broglie MA, Giger R, Klussmann JP, Evans M, Bourhis J, Leemans CR, Spriano G, Dietz A, Hunter K, Zimmermann F, Tinhofer I, Patterson JM, Quaglini S, Govaerts AS, Fortpied C, Simon C.
Front Oncol. 2019 Oct 22;9:999. doi: 10.3389/fonc.2019.00999. eCollection 2019.
PMID: 31696052
Influencing Factors on Radiotherapy Outcome in Stage I-II Glottic Larynx Cancer-A Multicenter Study.
Elicin O, Ermiş E, Oehler C, Aebersold DM, Caparrotti F, Zimmermann F, Studer G, Henke G, Adam L, Anschuetz L, Ozsahin M, Guckenberger M, Shelan M, Kaydıhan N, Riesterer O, Prestwich RJD, Spielmann T, Giger R, Şen M.
Front Oncol. 2019 Sep 20;9:932. doi: 10.3389/fonc.2019.00932. eCollection 2019.
PMID: 31616637
Elicin O, Broglie MA, Fankhauser N, Stoeckli SJ, Pasche P, Reinhard A, Bongiovanni M, Huber GF, Morand GB, Soltermann A, Arnold A, Dettmer MS, Arnoux A, Stauffer E, Espeli V, Martucci F, Aebersold DM, Giger R.
Head Neck. 2019 May;41(5):1395-1402. doi: 10.1002/hed.25574. Epub 2018 Dec 28.
PMID: 30593685
Dulguerov P, Broglie MA, Henke G, Siano M, Putora PM, Simon C, Zwahlen D, Huber GF, Ballerini G, Beffa L, Giger R, Rothschild S, Negri SV, Elicin O.
Front Oncol. 2019 Oct 24;9:1125. doi: 10.3389/fonc.2019.01125. eCollection 2019.
PMID: 31709185
Elicin O, Putora PM, Siano M, Broglie MA, Simon C, Zwahlen D, Huber GF, Ballerini G, Beffa L, Giger R, Rothschild S, Negri SV, Dulguerov P, Henke G.
Front Oncol. 2019 Oct 24;9:1126. doi: 10.3389/fonc.2019.01126. eCollection 2019.
PMID: 31709186
Siano M, Dulguerov P, Broglie MA, Henke G, Putora PM, Simon C, Zwahlen D, Huber GF, Ballerini G, Beffa L, Giger R, Rothschild S, Negri SV, Elicin O.
Front Oncol. 2019 Oct 24;9:1127. doi: 10.3389/fonc.2019.01127. eCollection 2019.
PMID: 31709187
Broglie MA, Dulguerov P, Henke G, Siano M, Putora PM, Simon C, Zwahlen D, Huber GF, Ballerini G, Beffa L, Giger R, Rothschild S, Negri SV, Elicin O.
Front Oncol. 2019 Oct 24;9:1128. doi: 10.3389/fonc.2019.01128. eCollection 2019.
PMID: 31709188
Nisa L, Francica P, Giger R, Medo M, Elicin O, Friese-Hamim M, Wilm C, Stroh C, Bojaxhiu B, Quintin A, Caversaccio MD, Dettmer MS, Buchwalder M, Brodie TM, Aebersold DM, Zimmer Y, Carey TE, Medová M.
Mol Cancer Ther. 2020 Feb;19(2):614-626. doi: 10.1158/1535-7163.MCT-18-1274. Epub 2019 Nov 19.
PMID: 31744898
Molecular patterns in salivary duct carcinoma identify prognostic subgroups.
Mueller S, Gauthier ME, Blackburn J, Grady J, Kraitsek S, Hajdu E, Dettmer M, Dahlstrom J, Soon Lee C, Luk P, Yu B, Giger R, Kummerfeld S, Clark J, Gupta R, Cowley M.
ModPathol (in press 2020) 6.3650.947
Emerging patient-specific treatment modalities in head and neck cancer – a systematic review
Elicin O, Cihoric N, Vlaskou Badra E, Ozsahin M.
Expert Opin Investig Drugs 2019;28(4),365-376
Development and validation of a targeted gene sequencing panel for application to disparate cancers
McCabe MJ, Gauthier MA, Chan C, Thompson TJ, De Sousa SMC, Puttick C, Grady JP,
Gayevskiy V, TaoJ, Ying K, Cipponi A, Deng N, Swarbrick A, Thomas ML, kConFab, Lord
RV, Johns AL, Kohonen-Corish M, O’Toole S, Clark JR, Mueller SA, Gupta R, McCormack
AI, Dinger ME, Cowley MJ.
Sci Rep. 2019;9(1):17052, IF 4.01
Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma
Mueller SA, Gauthier MA, Ashford B, Gupta R, Gayevskiy V, Ch’ng S, Palme CE, Shannon
K, Clark JR, Ranson M, Cowley MJ
J Invest Dermatol. 2019;139(7):1449-1458.e1, IF 6.29
Schürch CM, Roelli MA, Forster S, Wasmer MH, Brühl F, Maire RS, Di Pancrazio S, Ruepp MD, Giger R, Perren A, Schmitt AM, Krebs P, Charles RP, Dettmer MS.
Thyroid. 2019 Jul;29(7):979-992. doi: 10.1089/thy.2018.0555. Epub 2019 May 10.
PMID: 30938231
Publikations 2018
Elicin O, Broglie MA, Fankhauser N, Stoeckli SJ, Pasche P, Reinhard A, Bongiovanni M, Huber GF, Morand GB, Soltermann A, Arnold A, Dettmer MS, Arnoux A, Stauffer E, Espeli V, Martucci F, Aebersold DM, Giger R.
Head Neck. 2019 May;41(5):1395-1402. doi: 10.1002/hed.25574. Epub 2018 Dec 28.
PMID: 30593685
Elicin O, Sermaxhaj B, Bojaxhiu B, Shelan M, Giger R, Rauch D, Aebersold DM.
Strahlenther Onkol. 2019 Jun;195(6):468-474. doi: 10.1007/s00066-018-1400-5. Epub 2018 Nov 21.
PMID: 30465265
Bojaxhiu B, Templeton AJ, Elicin O, Shelan M, Zaugg K, Walser M, Giger R, Aebersold DM, Dal Pra A.
Radiat Oncol. 2018 Nov 6;13(1):216. doi: 10.1186/s13014-018-1159-y.
PMID: 30400969
Anschuetz L, Visini M, Shelan M, Elicin O, Giger R.
Head Neck. 2018 Nov;40(11):2469-2475. doi: 10.1002/hed.25373. Epub 2018 Oct 11.
PMID: 30307670
Nisa L, Barras D, Medová M, Aebersold DM, Medo M, Poliaková M, Koch J, Bojaxhiu B, Eliçin O, Dettmer MS, Angelino P, Giger R, Borner U, Caversaccio MD, Carey TE, Ho L, McKee TA, Delorenzi M, Zimmer Y.
Mol Cancer Res. 2018 Dec;16(12):1912-1926. doi: 10.1158/1541-7786.MCR-18-0056. Epub 2018 Aug 14.
PMID: 30108165
Aeberhard C, Mayer C, Meyer S, Mueller SA, Schuetz P, Stanga Z, Giger R.
Head Neck. 2018 May;40(5):1057-1067. doi: 10.1002/hed.25072. Epub 2018 Jan 24.
PMID: 29368455
Letter to the Editor on Nevens et al.
Elicin O, Giger R.
Radiother Oncol. 2018 Mar;126(3):570. doi: 10.1016/j.radonc.2017.12.016. Epub 2018 Jan 6. No abstract available.
PMID: 29317113
Giger R, Elicin O.
Laryngorhinootologie. 2018 Jan;97(1):8-10. doi: 10.1055/s-0043-121838. Epub 2018 Jan 4. German.
PMID: 29301156
Recurrent parotid gland carcinoma: how effective is salvage surgery?
Nisa L, Borner U, Dür C, Arnold A, Giger R.
Eur Arch Otorhinolaryngol. 2018 Feb;275(2):507-513. doi: 10.1007/s00405-017-4829-8. Epub 2017 Dec 1.
PMID: 29196807
Treatment of tracheoesophageal fistula after laryngectomy by a customized tracheal prosthesis.
Mueller SA, Dehnbostel S, Dehnbostel F, Giger R.
Laryngoscope. 2018 Aug;128(8):1858-1861. doi: 10.1002/lary.27027. Epub 2017 Nov 29. No abstract available.
PMID: 29193191
Part 1: Optimization and evaluation of dynamic trajectory radiotherapy.
Fix MK, Frei D, Volken W, Terribilini D, Mueller S, Elicin O, Hemmatazad H, Aebersold DM, Manser P.
Med Phys. 2018 Jul 10. doi: 10.1002/mp.13086. [Epub ahead of print]
PMID: 29992587
Glück AA, Orlando E, Leiser D, Poliaková M, Nisa L, Quintin A, Gavini J, Stroka DM, Berezowska S, Bubendorf L, Blaukat A, Aebersold DM, Medová M, Zimmer Y.
Oncogene. 2018 Jul;37(30):4181-4196. doi: 10.1038/s41388-018-0256-6. Epub 2018 May 2.
PMID: 29717265
MEK Inhibition Induces Therapeutic Iodine Uptake in a Murine Model of Anaplastic Thyroid Cancer.
ElMokh O, Taelman V, Radojewski P, Roelli MA, Stoss A, Dumont RA, Dettmer MS, Phillips WA, Walter MA, Charles RP.
J Nucl Med. 2019 Jul;60(7):917-923. doi: 10.2967/jnumed.118.216721. Epub 2018 Nov 21.
PMID: 30464041
Publikations 2017
Broglie MA, Stoeckli SJ, Sauter R, Pasche P, Reinhard A, de Leval L, Huber GF, Pezier TF, Soltermann A, Giger R, Arnold A, Dettmer M, Arnoux A, Müller M, Spreitzer S, Lang F, Lutchmaya M, Stauffer E, Espeli V, Martucci F, Bongiovanni M, Foerbs D, Jochum W.
Head Neck. 2017 Oct;39(10):2004-2015. doi: 10.1002/hed.24865. Epub 2017 Jul 10.
PMID: 28691255
Nisa L, Häfliger P, Poliaková M, Giger R, Francica P, Aebersold DM, Charles RP, Zimmer Y, Medová M.
Mol Cancer. 2017 May 22;16(1):93. doi: 10.1186/s12943-017-0660-5.
PMID: 28532501
18F-FDG PET/CT of Papillary Carcinoma in a Lateral Thyroglossal Duct Cyst.
Sachpekidis C, Dettmer MS, Weidner S, Giger R, Wartenberg J.
Clin Nucl Med. 2017 Aug;42(8):e371-e374. doi: 10.1097/RLU.0000000000001712.
PMID: 28525461
T1-2 glottic cancer treated with radiotherapy and/or surgery.
Shelan M, Anschuetz L, Schubert AD, Bojaxhiu B, Dal Pra A, Behrensmeier F, Aebersold DM, Giger R, Elicin O.
Strahlenther Onkol. 2017 Dec;193(12):995-1004. doi: 10.1007/s00066-017-1139-4. Epub 2017 May 4.
PMID: 28474090
NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis.
Peri S, Izumchenko E, Schubert AD, Slifker MJ, Ruth K, Serebriiskii IG, Guo T, Burtness BA, Mehra R, Ross EA, Sidransky D, Golemis EA.
Nat Commun. 2017 Nov 24;8(1):1772. doi: 10.1038/s41467-017-01877-7.
PMID: 29176703
Hakim A, Slotboom J, Lieger O, Schlittler F, Giger R, Michel C, Wiest R, Wagner F.
Dentomaxillofac Radiol. 2017 Apr;46(4):20160355. doi: 10.1259/dmfr.20160355. Epub 2017 Mar 7.
PMID: 28112538
Primary tumor volume delineation in head and neck cancer: missing the tip of the iceberg?
Elicin O, Terribilini D, Shelan M, Volken W, Mathier E, Dal Pra A, Aebersold DM, Fix MK, Manser P.
Radiat Oncol. 2017 Jun 20;12(1):102. doi: 10.1186/s13014-017-0838-4.
PMID: 28633674
The latest prospects of investigational drugs for head and neck cancer.
Elicin O, Ozsahin M.
Expert Opin Investig Drugs. 2017 Mar;26(3):265-268. doi: 10.1080/13543784.2017.1279145. Epub 2017 Jan 10. No abstract available.
PMID: 28056562
Bilateral lingual artery stenosis: A rare, late complication of chemoradiotherapy.
Holtz F, Monnier Y, Borner U, Nisa L.
Eur Ann Otorhinolaryngol Head Neck Dis. 2017 Sep;134(4):269-271. doi: 10.1016/j.anorl.2017.02.002. Epub 2017 Mar 11.
PMID: 28291634
Publikations 2016
- Elicin O, Nisa L, Dal Pra A, Bojaxhiu B, Caversaccio M, Schmücking M, Aebersold DM, Giger R. Up-front neck dissection followed by definitive (chemo)-radiotherapy in head and neck squamous cell carcinoma: Rationale, complications, toxicity rates, and oncological outcomes - A systematic review. Radiother Oncol. 2016 May;119(2):185-93. Pubmed
- Giger R. Head and neck cancer: update and innovations. Rev Med Suisse. 2016 Jan 27;12(503):188-91. Pubmed
- Elicin O, Albrecht T, Haynes AG, Bojaxhiu B, Nisa L, Caversaccio M, Dal Pra A, Schmücking M, Aebersold DM, Giger R. Outcomes in Advanced Head and Neck Cancer Treated with Up-front Neck Dissection prior to (Chemo)Radiotherapy. Otolaryngol Head Neck Surg. 2016 Feb;154(2):300-8. Pubmed
- Anschütz L, Nisa L, Elicin O, Bojaxhiu B, Caversaccio M, Giger R. Pectoralis major myofascial interposition flap prevents postoperative pharyngocutaneous fistula in salvage total laryngectomy. Eur Arch Otorhinolaryngol. 2016 Nov;273(11):3943-3949. Pubmed
- Medina J, Zbären P, Bradley PJ. Management of Regional Metastases of Malignant Salivary Gland Neoplasms. Adv Otorhinolaryngol. 2016;78:132-40. Pubmed
- Borner U, Stow NW, Landis BN. Pleomorphic Adenoma of the Parotid Gland. Am J Med. 2016 Jan;129(1):e1-2. Pubmed
- Cacicedo J, Navarro A, Del Hoyo O, Gomez-Iturriaga A, Alongi F, Medina JA, Elicin O, Skanjeti A, Giammarile F, Bilbao P, Casquero F, de Bari B, Dal Pra A. Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist. Br J Radiol. 2016 Nov;89(1067):20160217. Pubmed
- Elicin O, Ozsahin M. Current Role of Dacomitinib in Head and Neck Cancer. Expert Opin Investig Drugs. 2016 Jun;25(6):735-42. Pubmed
- Elicin O, Schmucking M, Bromme J, Rauch D, Ambarcioglu P, Plasswilm L, Geretschlager A, Ghadjar P, Giger R, Aebersold DM. Volumetric regression ratio of the primary tumor and metastatic lymph nodes after induction chemotherapy predicts overall survival in head and neck squamous cell carcinoma: a retrospective analysis. J BUON. 2016 Jan-Feb;21(1):175-81. Pubmed
- Merki V, Pichler J, Giger R, Mantokoudis G. Chylothorax in thyroid surgery: a very rare case and systematic review of the literature. J Otolaryngol Head Neck Surg. 2016 Oct 18;45(1):52. Pubmed
- Landis BN, Borner U. Neurofibromatosis of the tongue. Med J Aust. 2016 Oct 3;205(7):300. Pubmed
- Mattioli F, Presutti L, Caversaccio M, Bonali M, Anschuetz L. Novel Dissection Station for Endolaryngeal Microsurgery and Laser Surgery: Development and Dissection Course Experience. Otolaryngol Head Neck Surg. 2016 Sep 6. [Epub ahead of print] Pubmed
- Suter VG, Negoias S, Friedrich H, Landis BN, Caversaccio MD, Bornstein MM. Gustatory function and taste perception in patients with oral lichen planus and tongue involvement. Clin Oral Investig. Clin Oral Investig. 2017 Apr;21(3):957-964. Pubmed
- Stieger C, Arnold A, Kruse A, Wiedmer S, Widmer M, Guignard J, Schutz D, Guenat JM, Bachtler M, Caversaccio M, Uehlinger DE, Frey FJ, Hausler R. Novel Bone-Anchored Vascular Access on the Mastoid for Hemodialysis: Concept and Preclinical Trials. IEEE Trans Biomed Eng. 2016 May;63(5):984-990. Pubmed
Publikations 2015
- Geretschläger A, Bojaxhiu B, Dal Pra A, Leiser D, Schmücking M, Arnold A, Ghadjar P, Aebersold DM. Definitive intensity modulated radiotherapy in locally advanced hypopharygeal and laryngeal squamous cell carcinoma: mature treatment results and patterns of locoregional failure. Radiat Oncol. 2015 Jan 17;10:20. Pubmed
- Nisa L, Aebersold DM, Giger R, Caversaccio MD, Borner U, Medová M, Zimmer Y., Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches. Cancers (Basel). 2015 Mar 31;7(2):585-97. Pubmed
- Nisa L, Landis BN, Salmina C, Ailianou A, Karamitopoulou E, Giger R., Warthin's tumor of the larynx: a very rare case and systematic review of the literature. J Otolaryngol Head Neck Surg. 2015 May 12;44:16. Pubmed
- Nisa L, Salmina C, Dettmer MS, Arnold A, Aebersold DM, Borner U, Giger R., Implications of intraglandular lymph node metastases in primary carcinomas of the parotid gland. Laryngoscope. 2015 Sep;125(9):2099-106. Pubmed
- Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P. Etiology and management of recurrent parotid pleomorphic adenoma. Laryngoscope. 2015 Apr;125(4):888-93. Pubmed
- Mikami K, Medová M, Nisa L, Francica P, Glück AA, Tschan MP, Blaukat A, Bladt F, Aebersold DM, Zimmer Y. Impact of p53 Status on Radiosensitization of Tumor Cells by MET Inhibition-Associated Checkpoint Abrogation. Mol Cancer Res. 2015 Dec;13(12):1544-53. Pubmed
- Leiser D, Medová M, Mikami K, Nisa L, Stroka D, Blaukat A, Bladt F, Aebersold DM, Zimmer Y. KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells. Mol Oncol. 2015 Aug;9(7):1434-46. Pubmed